Report on Junior Scientist Symposium: Life Sciences
1. Rina Masadah: The origin of ovarian cancer may be found in the uterus: analysis of endometrial intraepithelial carcinoma in serous ovarian carcinoma
2. Retno Supriyanti: Cataract screening techniques under limited health facilities
3. Adhi Kristianto Sugianli: Antibiotic resistance on Escherichia coli and Klebsiella pneumonia
4. Aprilianto Eddy Wiria: Helminth infections and insulin sensitivity in Indonesians
The session was divided into 4 parts. In every part, the presenter presents his/her paper for 10-15 minutes and the floor was open for discussion for 5 minutes.
1. Rina Masadah: The origin of ovarian cancer may be found in the uterus: analysis of endometrial intraepithelial carcinoma in serous ovarian carcinoma.
Dr Masadah presented a very interesting cross-sectional study in 77 patients with ovarian cancer which looked at a potential association between serous ovarian carcinoma (SOC) and endometrial intraepithelial carcinoma (EIC) in support of the hypothesis that the latter might represent a precursor lesion for ovarian cancer. Indeed, concurrent EIC was found in more than 10% of SOC cases, the vast majority of which were highly similar to SOC with regards to P53 sequences and relevant protein expression profiles. The audience discussed whether the fact that EIC was found in only 10% of cases would limit the benefits of screening for EIC for early detection of SOC. However, according to dr Massadah, the low percentage might be due to sampling error and future studies should look at investigating larger endometrial areas. The need for additional prospective studies was highlighted.
2. Retno Supriyanti: Cataract screening techniques under limited health facilities.
Supriyanti presented her study on cataract screening techniques. Currently, most doctors in Indonesia using slit lamp to diagnose cataract and it is not feasible to use in remote area. She used specular reflections on ocular lens to differentiate mature cataract and normal eye and adjusted for some factors of reflections. The discussion was about the applicability of the technique to diagnose cataract in remote area, and also the possibilities to use camera phone which currently widely available in Indonesia, instead of using certain type of camera to capture the specular reflections. The technique is promising to assist the doctor or paramedic in remote area to diagnose cataract.
3. Adhi Kristianto Sugianli: Antibiotic resistance on Escherichia coli and Klebsiella pneumonia.
Dr Sugianli presented results of an 18 month hospital-based laboratory surveillance study at H.Sadikin Hospital in Bandung, involving almost 1500 isolates, which looked at the prevalence of antibiotic resistance in E. coli and K. pneumonia. His results indicated high (>60%) prevalences of resistance to most commonly used β lactam antibiotics and quinolones. These results are concerning and much discussion in the audience was focused on the need for appropriate antibiotic use and the need for adequate microbiology lab capacity and timely surveillance results to inform such appropriate antibiotic use. Both needs are currently addressed in a SPIN Joint Research Project in which Dr Sugianli participates extensively.
4. Aprilianto Eddy Wiria: Helminth infections and insulin sensitivity in Indonesia.
Wiria presented his study on helminth infection and insulin sensitivity. He found that people with helminth infection had lower insulin resistance compared to people without helminth infection. The discussion was about the association of helminth infection and their nutritional status related to this phenomenon. However, the presentation proposed the role of Th1 and Th2 induced by helminth infection for lowering insulin resistance.