Collaborative research under the SPIN program has brought rapid advancement of TB and HIV research in our institution. Subsequently, impact to the society is expected as the next output of these projects. Indonesian SPIN Investigators have been actively involved in providing contributions to research activities and technical assistance for the National Program. Several laboratory technologies derived from research projects has been utilized in clinical services. In spite of these positive progress, several challenges remain. Generally, overall capacity of human resource to conduct research is still low. Implementation of new laboratory techniques is hampered by the lack of supporting policies in many aspects. In funding, national resources are more directed towards biomedical product related research, having large discrepancy with interests of our counterparts. These facts remind us on some crucial requirements for research programs that could benefit the community as well as the collaborating partners.